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Consecutive measurements of serum trough levels and anti-infliximab antibodies are reliable in stable patients. These test could be used to lower or stop infliximab … High levels of ADAs may negate Infliximab efficacy. The serum concentration of Infliximab immediately prior to re-infusion (trough level) provides important information and should be used to inform dosing, clinical management and appropriate ADA testing; trough drug levels should be monitored during any changes in dosing regimen. Detectable trough level of infliximab, but less than 5 micrograms/ml. Infliximab dose increased by 50 mg or 100 mg. Trough levels of infliximab of greater than 10 micrograms/ml on at least 2 occasions.

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Room temperature: 48 hours ; Refrigerated In this issue of Gut, Seow et al (see page 49) report on an important study of the relationship between serum trough levels of infliximab and the long-term clinical outcome of acute steroid-refractory ulcerative colitis.1 The findings of their study are dramatic. Detectable trough serum infliximab was present in only 39% of 115 patients after a showed that serum infliximab trough concentrations (TCs) are correlated with clinical response, clinical remission, and mucosal healing in patients with IBD.9–12 In general, low infliximab TCs and the presence of ATI are associated with worse clinical outcomes and an infliximab TC within the interval of 3–7 mg/mL during maintenance There is some evidence in adults that higher serum infliximab (IFX) levels are needed to adequately treat fistulizing perianal Crohn’s disease (CD). However, data in children are lacking. We aimed to determine postinduction serum trough IFX levels that are associated with healing of fistulizing perianal CD (PCD) at week 24. Imaeda H, Bamba S, Takahashi K, et al: Relationship between serum infliximab trough levels and endoscopic activities in patients with Crohn's disease under scheduled maintenance treatment. J Gastroenterol.

2014 Apr;49(4):674-82. doi: 10.1007/s00535-013-0829-7.

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Seventeen patients (14.5%) had detectable antibodies to infliximab. Trough Concentrations of Infliximab Guide Dosing for Patients With Inflammatory Bowel Disease Niels Vande Casteele,1 Marc Ferrante,2 Gert Van Assche,2 Vera Ballet,2 Griet Compernolle,1 Kristel Van Steen,3,4 Steven Simoens,5 Paul Rutgeerts,2 Ann Gils,1,§ and Séverine Vermeire2,§ 1Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Therapeutic and Diagnostic Antibodies, … side effects, or hypersensitivity and serum TNF-a, IFX trough levels, and ATI concentrations.

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Relationship between serum trough infliximab levels, serum antibodies to infliximab, serum albumin levels and clinical response to infliximab treatment in patients with inflammatory bowel diseases Karin Malickova1, Ivana Janatkova1, Helena Brodska1, Dana Duricova2, Martin Bortlik2, Tomas Zima1 and Milan Lukas1,2 Abstract. The role of trough serum infliximab (s-IFX) and antibodies toward IFX (ATI) during maintenance treatment remains unclear in children. The aim of the present study was to investigate trough s-IFX and ATI to identify any correlation with inflammatory activity and clinical response in a pediatric inflammatory bowel disease (IBD) cohort. The association between serum Ifx trough levels at early stages and clinical response at W52 was evaluated. After that, receiver operating characteristic (ROC) curves for the outcome of clinical response after 52W of treatment were employed to determine the best cut-off values for serum Ifx trough levels. Low infliximab serum trough levels and anti-infliximab antibodies are prevalent in rheumatoid arthritis patients treated with infliximab in daily clinical practice: results of an observational cohort study.

Methods: Disease activity and serum trough infliximab levels before and 2, 6, and 14 weeks after initiation of infliximab treatment at a dose of 3 mg/kg in a cohort of 105 patients with RA were assessed.
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2015-05-12 · Patients receiving maintenance infliximab for Crohn disease could benefit from an infliximab trough level, followed by dosage adjustment for levels outside the range of 3 to 7 µg/mL. Once the target level has been achieved, little is gained by additional trough level measurements during stable, continuing maintenance therapy. Serum infliximab trough levels ≥3.5 µg/mL and ≥60% CRP decrease were significantly associated with durable sustained response.

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demonstrated that higher serum IFX trough levels at weeks 2 and 6 were associated with higher rates of healing at weeks 14 and 30 in 36 adults with fistulizing perianal CD. 16 The area under the curve (AUC) for association of IFX level at week 2 with fistula improvement at week 14 was 0.94 (P = 0.0001). 16 A serum IFX level of 9.25 µg/mL was predictive of fistula response at week 14, with a sensitivity of 89% and a specificity of 90%. showed that serum infliximab trough concentrations (TCs) are correlated with clinical response, clinical remission, and mucosal healing in patients with IBD.9–12 In general, low infliximab TCs and the presence of ATI are associated with worse clinical outcomes and an infliximab TC within the interval of 3–7 mg/mL during maintenance Infliximab Trough Levels and Doses The median IFX trough level was 2.8 mg/L (Table 2).